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The absolute bioavailability is the dose-corrected area under curve (AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered). Therefore, a drug given by the intravenous route will have an absolute ...
Religion and drugs. Many religions have expressed positions on what is acceptable to consume as a means of intoxication for spiritual, pleasure, or medicinal purposes. Psychoactive substances may also play a significant part in the development of religion and religious views as well as in rituals. [1][2][3][4][5] The most common drugs in the ...
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]). In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used ...
Intranasal drug delivery. Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system. Though pharmaceuticals can be injected into the nose, some concerns include injuries, infection, and safe disposal. Studies demonstrate improved patient compliance with inhalation.
Artemisinin. Artemisinin (/ ˌɑːrtɪˈmiːsɪnɪn /) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. [1] It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. [2]
Example: cimetidine; The absorption is limited by the permeation rate but the drug is solvated very fast. If the formulation does not change the permeability or gastro-intestinal duration time, then class I criteria can be applied. Class IV - low permeability, low solubility . Example: Bifonazole; Those compounds have a poor bioavailability.
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.
A rectal "bulb" syringe for introducing a small amount of fluid into the rectum. Enema equipment for introducing a large amount of fluid into the colon via the rectum. Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's ...