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A nicotine base and a weak acid such as benzoic acid or levulinic acid is used to form a nicotine salt. [1] Across a sample of 23 nicotine salts available for public purchase, the three most common acids used in the formation of nicotine salts were lactic acid, benzoic acid and levulinic acid. [8]
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
A potentially fatal dose for a child is 0.1–0.2 mg/kg of body weight, [93] or 6 mg. [76] [202] A fatal dose for an adult is 0.5–1 mg/kg [93] or about 30–60 mg. [203] However the widely-used human LD 50 estimate of around 0.8 mg/kg was questioned in a 2013 review, in light of documented cases of humans surviving much higher doses; the ...
The Mayo Clinic diet was created by weight management practitioners at the Mayo Clinic and was designed as a lifestyle change program to promote gradual and sustained weight loss, says Melissa ...
Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) [9] and is widely used recreationally as a stimulant and anxiolytic.
Mayo Clinic is a nonprofit hospital system with campuses in Rochester, Minnesota; Scottsdale and Phoenix, Arizona; and Jacksonville, Florida. [22] [23] Mayo Clinic employs 76,000 people, including more than 7,300 physicians and clinical residents and over 66,000 allied health staff, as of 2022. [5]
Nicotine polacrilex is nicotine bound to an ion-exchange resin (polymethacrylic acid, such as Amberlite IRP64, Purolite C115HMR or Doshion P551). [4] It is added to gum and hard lozenges used for nicotine replacement therapy in smoking cessation, such as in the Nicorette range of products.
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