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The cerebellar peduncles are three paired bundles of fibres that connect the cerebellum to the brain stem. [1] Superior cerebellar peduncle is a paired structure of white matter that connects the cerebellum to the mid-brain. Middle cerebellar peduncles connect the cerebellum to the pons and are composed entirely of centripetal fibers.
Cerebellar degeneration is a condition in which cerebellar cells, otherwise known as neurons, become damaged and progressively weaken in the cerebellum. [1] There are two types of cerebellar degeneration; paraneoplastic cerebellar degeneration , and alcoholic or nutritional cerebellar degeneration. [ 2 ]
The cerebral peduncles (In Latin, ped-means 'foot'.) are the two stalks that attach the cerebrum to the brainstem. [1] They are structures at the front of the midbrain which arise from the ventral pons and contain the large ascending (sensory) and descending (motor) tracts that run to and from the cerebrum from the pons.
Cerebral atrophy is a common feature of many of the diseases that affect the brain. [1] Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them.
The middle cerebellar peduncle is the largest of the three cerebellar peduncles. It connects the pons and cerebellum.It consists almost entirely of fibers passing from the pons to the cerebellum (fibrocerebellar fibers); the fibers arise from the pontine nuclei and decussate within the pons before entering the peduncle [1] to end in the contralateral cerebellar hemisphere.
The inferior cerebellar peduncle is the smallest of the three cerebellar peduncles. The upper part of the posterior district of the medulla oblongata is occupied by the inferior cerebellar peduncle, a thick rope-like strand situated between the lower part of the fourth ventricle and the roots of the glossopharyngeal and vagus nerves.
Cerebellar atrophy has been observed in many other neurological disorders including Huntington's disease, multiple sclerosis, [60] essential tremor, progressive myoclonus epilepsy, and Niemann–Pick disease. Cerebellar atrophy can also occur as a result of exposure to toxins including heavy metals or pharmaceutical or recreational drugs. [65]
Pontocerebellar hypoplasia (PCH) is a heterogeneous group of rare neurodegenerative disorders caused by genetic mutations and characterised by progressive atrophy of various parts of the brain such as the cerebellum or brainstem (particularly the pons). [1]