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[2] [4] Acetazolamide is in the diuretic and carbonic anhydrase inhibitor families of medication. [2] It works by decreasing the formation of hydrogen ions and bicarbonate from carbon dioxide and water. [2] Acetazolamide came into medical use in 1952. [7] It is on the World Health Organization's List of Essential Medicines. [8]
Acetazolamide is an inhibitor of carbonic anhydrase.It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.
The carbonic anhydrases (or carbonate dehydratases) (EC 4.2.1.1) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). [1] The active site of most carbonic anhydrases contains a zinc ion.
Aquaporin. Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. [1] The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through ...
The following chart shows the solubility of various ionic compounds in water at 1 atm pressure and room temperature (approx. 25 °C, 298.15 K). "Soluble" means the ionic compound doesn't precipitate, while "slightly soluble" and "insoluble" mean that a solid will precipitate; "slightly soluble" compounds like calcium sulfate may require heat to precipitate.
Brinzolamide. Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide was approved as a generic medication in the United States in November 2020. [2]
Osmotic diuretic. An osmotic diuretic is a type of diuretic that inhibits reabsorption of water and sodium (Na). They are pharmacologically inert substances that are given intravenously. They increase the osmolarity of blood and renal filtrate. [1] This fluid eventually becomes urine.
Studies indicate that microplastic levels in bottled water tend to be higher than those found in tap water. Concentrations can range from a mere 0.0001 particles per liter to a staggering 930 ...