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Frederick Griffith (1877–1941) was a British bacteriologist whose focus was the epidemiology and pathology of bacterial pneumonia. In January 1928 he reported what is now known as Griffith's Experiment , the first widely accepted demonstrations of bacterial transformation , whereby a bacterium distinctly changes its form and function .
Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria. Griffith's experiment, [1] performed by Frederick Griffith and reported in 1928, [2] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
Horizontal gene transfer was first observed in 1928, in Frederick Griffith's experiment: showing that virulence was able to pass from virulent to non-virulent strains of Streptococcus pneumoniae, Griffith demonstrated that genetic information can be horizontally transferred between bacteria via a mechanism known as transformation. [2]
Griffith's experiment, reported in 1928 by Frederick Griffith, [23] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
January – Frederick Griffith reports the results of Griffith's experiment, indirectly proving the existence of DNA. [1] [2]September 28 – Scottish-born microbiologist Alexander Fleming, at St Mary's Hospital, London, accidentally rediscovers the antibiotic which he will call Penicillin, [3] [4] forgotten since Ernest Duchesne's original discovery in 1896.
Transformation in bacteria was first demonstrated in 1928 by the British bacteriologist Frederick Griffith. [3] Griffith was interested in determining whether injections of heat-killed bacteria could be used to vaccinate mice against pneumonia.
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In Griffith's experiment, mice are injected with dead bacteria of one strain and live bacteria of another, and develop an infection of the dead strain's type. 1928: Frederick Griffith discovers that hereditary material from dead bacteria can be incorporated into live bacteria.