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Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell. Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals.
A single dendrotoxin molecule associates reversibly with a potassium channel in order to exert its inhibitory effect. It is proposed that this interaction is mediated by electrostatic interactions between the positively charged amino acid residues in the cationic domain of dendrotoxin and the negatively charged residues in the ion channel pore.
Class III antiarrhythmic drugs are potassium channel blockers that cause QT prolongation and are associated with TdP. Amiodarone. Amiodarone works in many ways. It blocks sodium, potassium, and calcium channels, as well as alpha and beta adrenergic receptors. Because of its multiple actions, amiodarone causes QT prolongation but TdP is rarely ...
Inward-rectifier potassium ion channel: Cystic fibrosis: Chloride channel Dravet syndrome: Voltage-gated sodium channel: Episodic ataxia: Voltage-gated potassium channel: Erythromelalgia: Voltage-gated sodium channel Generalized epilepsy with febrile seizures plus: Voltage-gated sodium channel Familial hemiplegic migraine: various
hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as K v 11.1, the alpha subunit of a potassium ion channel.This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel mediates the repolarizing I Kr current in the cardiac action potential, which helps coordinate the heart ...
A potassium channel opener is a type of drug which facilitates ion transmission through potassium ... Potassium channel blocker; References This page was last ...
Ion channels are typically categorised by gating mechanism and by the ion they conduct. Note that an ion channel may overlap between different categories. Some channels conduct multiple ion currents and some are gated by multiple mechanisms. Examples of targets for modulators include: Voltage-gated ion channels