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Idiopathic guttate hypomelanosis is characterised by multiple small whitish flat spots. [1] They are typically irregular, well defined and frequently appear on the arms, legs, and faces of older people. [1] It occurs in up to 80% of people over 70 years old. [2] Females may notice it at a younger age than males. [3]
Initial Cause of Discoloration: Treatment: Idiopathic guttate hypomelanosis: No treatment Postinflammatory hypopigmentation: Treat the underlying inflammatory disease to restore pigmentation Pityriasis versicolor: A topical ointment, such as selenium sulfide 2.5% or imidazoles. Can also use oral medications, such as oral imidazoles or triazoles ...
Type 1 is associated with neurological abnormalities. These include delayed development, intellectual disability, seizures, hypotonia and eye abnormalities. Type 2 - unlike type 1 - is not associated with primary neurological disease but is associated with an uncontrolled T lymphocyte expansion and macrophage activation syndrome.
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The most frequent cause of low melanin concentration (hypopigmentation) is prior skin trauma, which includes skin lesions including blisters, burns, infections, exposure to chemicals, and other wounds. The skin will appear paler than the surrounding skin surface once an injury has healed.
Periorbital hyperpigmentation, also known as hereditary dark circles, is characterized by darker skin around the eyes caused by the presence of additional melanin. It is an extremely common hereditary human characteristic and is frequently found on individuals with dark skin. Periorbital hyperpigmentation is most prevalent within the 16–25 ...
BCEM, also referred to as conjunctival hypermelanosis, complexion-associated melanosis, or racial melanosis, is a non-cancerous lesion of the conjunctiva that is more commonly found in dark-skinned individuals (over 90% of lesions are found in black persons and around 5% in white persons). [1]
Mucosal lentigines (labial and penile and vulvar melanosis, melanotic macules) Nevus of Ito (nevus fuscoceruleus acromiodeltoideus) Nevus of Ota (congenital melanosis bulbi, melanosis bulborum and aberrant dermal melanocytosis, nevus fuscoceruleus ophthalmomaxillaris, oculodermal melanocytosis, oculomucodermal melanocytosis)