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  2. List of polysubstance combinations - Wikipedia

    en.wikipedia.org/wiki/List_of_polysubstance...

    Alcohol: Cannabis: Tincture of cannabis. Herb and Al. Judgement Day Cross fading, twisting, getting twisted [13] Called Judgement Day in Ghana when cannabis is added to the drink Alcohol: Cocaine: Snow-cone Snow-coning Ethanol is metabolized into cocaethylene [14] Alcohol: MDMA: Tipsy flip Tipsy flipping It may be dangerous Alcohol: Nicotine ...

  3. Polysubstance use - Wikipedia

    en.wikipedia.org/wiki/Polysubstance_use

    For example: Benzodiazepines can cause death when mixed with other CNS depressants such as opioids, alcohol, or barbiturates. [7] [8] [9] GHB combined with alcohol can lead to a long-lasting coma-like state (‘G-sleep’) or even accidental death, particularly in light of GHB's narrow threshold for overdose. Depressants combined with ...

  4. Combined drug intoxication - Wikipedia

    en.wikipedia.org/wiki/Combined_drug_intoxication

    Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death .

  5. List of deaths from drug overdose and intoxication - Wikipedia

    en.wikipedia.org/wiki/List_of_deaths_from_drug...

    For example, while opium and coca had been used for centuries, their active ingredients, morphine and the cocaine alkaloid, were not isolated until 1803 and 1855 respectively. [ 5 ] [ 6 ] Cocaine and various opiates were subsequently mass-produced and sold openly and legally in the Western world , resulting in widespread misuse and addiction.

  6. Cross-tolerance - Wikipedia

    en.wikipedia.org/wiki/Cross-tolerance

    Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters.

  7. Oxycodone - Wikipedia

    en.wikipedia.org/wiki/Oxycodone

    Oxycodone, a semi-synthetic opioid, is a highly selective full agonist of the μ-opioid receptor (MOR). [41] [42] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [19] Oxycodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly.

  8. List of Schedule II controlled substances (U.S.) - Wikipedia

    en.wikipedia.org/wiki/List_of_Schedule_II...

    This is the list of Schedule II controlled substances in the United States as defined by the Controlled Substances Act. [1] The following findings are required, by section 202 of that Act, for substances to be placed in this schedule: The drug or other substance has a high potential for abuse.

  9. List of psychotropic medications - Wikipedia

    en.wikipedia.org/wiki/List_of_psychotropic...

    Librium (chlordiazepoxide) – a benzodiazepine used to treat acute alcohol withdrawal; Lithobid, Eskalith – a mood stabilizer; Loxam (escitalopram) – an antidepressant of the SSRI class; Lunesta (eszopiclone) – a non-benzodiazepine hypnotic; Luvox (fluvoxamine) – an antidepressant of the SSRI class