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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen activity is strictly associated with the CNS. Muscle relaxants are thought to be useful in painful disorders based on the theory that pain induces spasm and spasm causes pain.
Iron deficiency can also cause shortness of breath, and amplify the symptoms of any chronic condition, such as depression. It can also have an affect on your mood, ability to focus and sleep quality .
Treatment usually entails gradually reducing the dosage over a period of weeks or several months, depending on the individual, dosage, and length of time the drug has been taken. If this approach fails, a crossover to a benzodiazepine equivalent dose of a long-acting benzodiazepine (such as chlordiazepoxide or, more preferably, diazepam ) can ...
There is no lesion or physical damage, but hypertonia of the pelvic floor could be one cause. [38] It affects men of all ages, but especially from middle-age onward. [38] Several pharmacologic treatments such as propranolol, clozapine, clonazepam, baclofen and various antidepressants are considered effective. [37]
Benzodiazepines are well known for their strong muscle-relaxing properties and can be useful in the treatment of muscle spasms, [24]: 577–578 although tolerance often develops to their muscle relaxant effects. [15] Baclofen [71] or tizanidine are sometimes used as an alternative to benzodiazepines. Tizanidine has been found to have superior ...
In individuals deprived of sleep, somnolence may spontaneously dissipate for short periods of time; this phenomenon is the second wind, and results from the normal cycling of the circadian rhythm interfering with the processes the body carries out to prepare itself to rest. The word "somnolence" is derived from the Latin "somnus" meaning "sleep".
Then, after 15 minutes, the brain's anterior cortical regions receive normal daytime blood flow. This 15 minute time period corresponds to the sleep inertia period. [citation needed] Studies show that drinking alcoholic beverages in the evening causes physiological distress upon wake up. This phenomenon is known colloquially as a hangover. [10 ...