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Thymosin α 1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. [ 5 ] It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.
NMR structure of a β-thymosin. Both thymosin α 1 [1] and β-thymosins are intrinsically unstructured proteins, i.e. they lack a stable fold when free in aqueous solution. This structure, mostly alpha helix, was artificially stabilised by an organic solvent. [2] The thymosin illustrated, originally named β 9 is the cow orthologue of human β 10
Known as "Thymosin Fraction 5", this was able to restore some aspects of immune function in animals lacking thymus gland. Fraction 5 was found to contain over 40 small peptides (molecular weights ranging from 1000 to 15,000 Da.), [ 4 ] which were named "thymosins" and classified as α, β and γ thymosins on the basis of their behaviour in an ...
Thymosin α1 (TA1), a molecule with immune enhancing properties, was the first of the thymosins to enter clinical trials. [3] It has been approved in China and more than 30 other countries, [4] and has shown great promise in the treatment of severe sepsis, cancer, and a number of other diseases including the potential treatment of cystic fibrosis. [5]
The following is a list of hormones found in Humans. Spelling is not uniform for many hormones. For example, current North American and international usage uses [citation needed] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier spelling gonadotrophin.
TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes.