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There is little modern clinical research on Dioscorea villosa, and the one study of a wild yam-containing cream for menopausal symptoms failed to find any value from this therapy. [18] According to the American Cancer Society, there is no evidence to support wild yam or diosgenin being either safe or effective in humans. [19]
Wild yam (or Chinese yam) – types of yam, the roots of which are made into creams and dietary supplements that are promoted for a variety of medicinal purposes, including cancer prevention. The American Cancer Society says of these products, "available scientific evidence does not support claims that they are safe or effective."
Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam species, such as the Kokoro. It is also present in smaller amounts in a number of other species.
That includes a current or past hormone receptor-positive cancer (primarily breast and endometrial cancers), as well as a history of stroke, blood clots or cardiovascular disease, Barbieri explains.
As of 2019, only 32.9% of cancer patients in the United States died within five years of their diagnosis. [7] Despite their effectiveness, many conventional treatments are accompanied by a wide range of side effects, including pain, fatigue, and nausea. [8] [9] Some side effects can even be life-threatening.
May worsen hormone sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids. [17] Insomnia. [17] Goldenseal: orangeroot, yellow puccoon Hydrastis canadensis: Uterotonic [3] Greater celandine: celandine Chelidonium majus: Liver damage [4] Guarana: Paullinia cupana: Agitation and insomnia [3 ...