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Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]
The incidence of life-threatening hypersensitivity reactions occurring during surgery and anesthesia is around one in 10,000 procedures. [1] Severe allergic reactions to anesthetic medications are rare and are usually attributable to factors other than the anesthetic.
The problem can occur when the movements involved in swallowing are restricted due to a tumor, any type of blockage, or paralysis after a stroke. Besides the motor problems, swallowing can be impaired due to sensory dysfunction, meaning when sensation (the ability to feel) is lost or reduced anywhere in the throat area.
Dysesthesia is an unpleasant, abnormal sense of touch. Its etymology comes from the Greek word "dys," meaning "bad," and "aesthesis," which means "sensation" (abnormal sensation). It often presents as pain [1] but may also present as an inappropriate, but not discomforting, sensation.
Hyperalgesia (/ ˌ h aɪ p ər æ l ˈ dʒ iː z i ə / or /-s i ə /; hyper from Greek ὑπέρ (huper) 'over' + -algesia from Greek ἄλγος (algos) 'pain') is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus.
Sensory processing disorder (SPD), formerly known as sensory integration dysfunction, is a condition in which multisensory input is not adequately processed in order to provide appropriate responses to the demands of the environment.
Hypoesthesia or numbness is a common side effect of various medical conditions that manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli. In everyday speech this is generally referred to as numbness. [1]
People with autism experience auditory hypersensitivity which can lead to sensory overload. [23] Although people with autism do not have abnormalities in P50 sensory gating, they have anomalies in sensory gating related to the N100 test which indicates an irregularity in attention-related direction and top-down mental pathways. [ 23 ]