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[42] [43] Hydralazine and its derivatives are also used in the treatment of severe hypertension, although they should be avoided in emergencies. [43] They are no longer indicated as first-line therapy for high blood pressure due to side effects and safety concerns, but hydralazine remains a drug of choice in gestational hypertension. [42]
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Resistant hypertension is defined as hypertension that remains above goal blood pressure in spite of using, at once, three antihypertensive medications belonging to different drug classes. Guidelines for treating resistant hypertension have been published in the UK [ 45 ] and US. [ 46 ]
Doctors will often recommend a low dose of medication at first, but people with hypertension may need to combine two or more drugs to manage their blood pressure, depending on the person and any ...
Adequate management of hypertension can be hampered by inadequacies in the diagnosis, treatment, or control of high blood pressure. [185] Health care providers face many obstacles to achieving blood pressure control, including resistance to taking multiple medications to reach blood pressure goals.
Amlodipine is most often used to treat systemic hypertension in both cats and dogs. [62] In cats, it is the first line of treatment due to its efficacy and few side effects. [ 63 ] Systemic hypertension in cats is usually secondary to another abnormality, such as chronic kidney disease , and so amlodipine is most often administered to cats with ...