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Promestriene (INN Tooltip International Nonproprietary Name) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic estrogen which is used topically in a 1% cream formulation for the treatment of vaginal atrophy in women.
An estrogen preparation very similar to CEEs but differing in source and composition is esterified estrogens. [1] In 2020, it was the 283rd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [17] [18]
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
The hormone estriol, produced during pregnancy, is frequently compounded into bioidentical preparations in the United States. While some think it to be a weaker estrogen, with a more limited period of effectiveness than estradiol, it has been demonstrated to be a stronger estrogen in certain ways. [22]
Estrone is an estrogen, specifically an agonist of the estrogen receptors (ERs) ERα and ERβ. [5] [44] It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. [5] [44] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [45]
Optometrist Dr. Meenal Agarwal says that “during and after menopause, estrogen levels fluctuate, which affects pain receptors in the brain. Therefore, changes in estrogen can trigger headaches ...
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