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Digitalis (/ ˌ d ɪ dʒ ɪ ˈ t eɪ l ɪ s / [3] or / ˌ d ɪ dʒ ɪ ˈ t æ l ɪ s / [4]) is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves. Digitalis is native to Europe, Western Asia, and northwestern Africa. The flowers are tubular in shape, produced on a tall spike, and vary in ...
Digoxin has the ability to bind oestrogen receptors, and therefore it has been proposed that it might increase the risk of oestrogen-sensitive breast and uterine cancers. [62] A large Danish study found a complicated picture, with slightly increased risk of breast cancer amongst women taking digoxin, but better prognostic features. [63]
Digitalis purpurea, the foxglove or common foxglove, is a toxic species of flowering plant in the plantain family Plantaginaceae, [2] native to and widespread throughout most of temperate Europe. [3] It has also naturalized in parts of North America, as well as some other temperate regions.
It came into use in treating cardiac disease in late 18th century England in spite of its high toxicity. a Its use has been almost entirely replaced by the pharmaceutical derivative Digoxin, which has a shorter half-life in the body, and whose toxicity is therefore more easily managed. [54] Digoxin is used as an antiarrhythmic agent and ...
α-Acetyldigoxin is a cardiac glycoside found in plants of the genus Digitalis, including Digitalis lanata. [1] It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin . α-Acetyldigoxin increases the contractility of the heart by its positive inotropic effect on cardiac muscle .
It has been argued that "the use of natural products has been the single most successful strategy in the discovery of novel medicines". [ 3 ] Plants need to defend themselves from attack by micro-organisms, in particular fungi, and they do this by producing anti-fungal chemicals that are toxic to fungi.
Digitalis obscura is a shrub or herbaceous perennial growing from a woody base, reaching 1 to 3.9 feet (0.30 to 1.19 m) tall. [6] The stems are smooth and erect. The long leaves are basal and form in a rosette fashion, growing outward closer to the ground.
Digitalis lanata is a biennial or perennial growing from a woody, horizontal rootstock. [7] There is a tidy rosette before the spike goes up, and it is neatly arranged around the purple-tinged stems. The plant commonly forms a single, upright, more or less uniformly leafy stem that is partly ascending at the base. [ 7 ]