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Digitalis (/ ˌ d ɪ dʒ ɪ ˈ t eɪ l ɪ s / [3] or / ˌ d ɪ dʒ ɪ ˈ t æ l ɪ s / [4]) is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves. Digitalis is native to Europe, Western Asia, and northwestern Africa. The flowers are tubular in shape, produced on a tall spike, and vary in ...
Digoxin has the ability to bind oestrogen receptors, and therefore it has been proposed that it might increase the risk of oestrogen-sensitive breast and uterine cancers. [62] A large Danish study found a complicated picture, with slightly increased risk of breast cancer amongst women taking digoxin, but better prognostic features. [63]
May worsen hormone sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids. [17] Insomnia. [17] Goldenseal: orangeroot, yellow puccoon Hydrastis canadensis: Uterotonic [3] Greater celandine: celandine Chelidonium majus: Liver damage [4] Guarana: Paullinia cupana: Agitation and insomnia [3 ...
The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar and an R group. [4] The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity. [4]
It came into use in treating cardiac disease in late 18th century England in spite of its high toxicity. a Its use has been almost entirely replaced by the pharmaceutical derivative Digoxin, which has a shorter half-life in the body, and whose toxicity is therefore more easily managed. [54] Digoxin is used as an antiarrhythmic agent and ...
The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. 2019. hdl: 10665/330668. ISBN 978-92-4-121030-0.
α-Acetyldigoxin is a cardiac glycoside found in plants of the genus Digitalis, including Digitalis lanata. [1] It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin . α-Acetyldigoxin increases the contractility of the heart by its positive inotropic effect on cardiac muscle .
Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong ...