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Hantavirus pulmonary syndrome (HPS), also called hantavirus cardiopulmonary syndrome (HCPS), is a severe respiratory disease caused by hantaviruses. The main features of illness are microvascular leakage and acute respiratory distress syndrome. Symptoms occur anywhere from 1 to 8 weeks after exposure to the virus and come in three distinct phases.
Leptospirosis is a blood infection caused by the bacterium Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild (headaches, muscle pains, and fevers) to severe (bleeding in the lungs or meningitis). [5]
Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection leads to HPS, an illness characterized by an early phase of mild and moderate symptoms such as fever, headache, and fatigue, followed by sudden respiratory failure.
Transmission electron micrograph of the Sin Nombre virus, the virus responsible for the outbreak. The spherical particles are virus bodies (virions). The 1993 Four Corners hantavirus outbreak was an outbreak of hantavirus disease that occurred in the Four Corners region of the US states in Arizona, Colorado, and New Mexico.
White lung syndrome, or white lung pneumonia, is getting attention after an outbreak in Ohio. Experts explain symptoms, causes, treatment, and prevention.
Rat-bite fever (RBF) is an acute, febrile human illness caused by bacteria transmitted by rodents, in most cases, which is passed from rodent to human by the rodent's urine or mucous secretions. Alternative names for rat-bite fever include streptobacillary fever, streptobacillosis, spirillary fever, bogger, and epidemic arthritic erythema.
For HPS, initial symptoms are flu-like, with fever, headache, and muscle pain, followed by sudden respiratory failure. HPS has a much higher case fatality rate than HFRS, at 30–60%. For both HFRS and HPS, illness is the result of increased vascular permeability, decreased platelet count, and overreaction of the immune system.
This causes the hallmark symptoms of HPS, including shortness of breath, coughing, and chest tightness as the liquid builds up in the lungs. The virus may also affect the heart and kidneys via further endothelial disruption in blood vessels, leading to systemic complications in severe cases.