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As with humans, obesity can cause numerous health problems in dogs (although dogs are much less susceptible to the common cardiac and arterial consequences of obesity than humans are). According to a study published in the Journal of Veterinary Internal Medicine , the prevalence of obesity in dogs is between 22 and 40 percent.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
Although symptoms can be mild, in some dogs this can become gangrenous mastitis and lead to death. The puppies most commonly die, but when a dog develops gangrenous mastitis, death is more common (2).
The canine distemper vaccination in particular has been a suspected causal factor due to the significant number of overlapping symptoms observed between systemically affected HOD puppies and dogs suffering from distemper, [9] but to-date, no definitive linkage has been demonstrated. [10] The cause of canine HOD largely remains unknown.
Media reporting on statins is often negative, and patient leaflets inform patients that rare but potentially serious muscle problems can occur during statin treatment. These create expectations of harm. Nocebo symptoms are real and bothersome and are a major barrier to treatment.
Although young growing dogs have immature gastrointestinal tracts, they do contain microflora which can ferment fibre and generate short chain fatty acids beneficial to gut health. [ 22 ] [ 23 ] Colonization and establishment of these bacterial populations happens over time, beginning immediately after birth. [ 24 ]
Since the hip cannot move fully, the body compensates by adapting its use of the spine, often causing spinal, stifle (a dog's knee joint), or soft tissue problems to arise. [citation needed] The causes of hip dysplasia are considered heritable, but new research conclusively suggests that environment also plays a role. [8]
The following rare side effects are more serious. Like all statins, rosuvastatin can possibly cause myopathy, rhabdomyolysis: [14] [4] muscle pain, tenderness, or weakness; lack of energy; fever; chest pain; jaundice: yellowing of the skin or eyes; dark colored, or foamy urine; pain in the upper right part of the abdomen; nausea; extreme ...