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For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.
Whereas TOC AUC varies between 0 and 1 — with an uninformative classifier yielding 0.5 — the alternative measures known as informedness, [citation needed] Certainty [12] and Gini coefficient (in the single parameterization or single system case) [citation needed] all have the advantage that 0 represents chance performance whilst 1 ...
Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. [4] AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [5]
Phi measures how better (or worse) is a classification, with respect to the random classification, which is characterized by Phi = 0. According to the reference values suggested by Cohen, [8] one can take Phi = 0.35 as a minimum acceptable level of Phi for a classification. In the ROC space, Phi equal to a non null constant corresponds to the ...
Meanwhile, in years when GDP tracked between 2.1% and 3%, stocks were higher 70% of the time, with an average return of nearly 11%. There is, of course, a chance the growth doesn't deliver.
A bioequivalency profile comparison of 150 mg extended-release bupropion as produced by Impax Laboratories for Teva and Biovail for GlaxoSmithKline. Bioequivalence is a term in pharmacokinetics used to assess the expected in vivo biological equivalence of two proprietary preparations of a drug. If two products are said to be bioequivalent it ...
At any point in time, any stock may be the best to buy, because stocks can fluctuate a lot over the short term. But the stocks that increase in value over time grow their sales and profits year ...
While many Americans believe that the stock market is an effective way to build wealth, the keys to successful investing are starting early and thinking long-term. Getting rich quickly is possible,...