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The Guinea pig maximisation test (GPMT) is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by B. Magnusson and Albert Kligman in 1969 [ 1 ] and described in their 1970 book Allergic Contact Dermatitis in the Guinea Pig .
The Buehler test is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon Buehler in 1965 [1] and further explained in 1980. [2] It is a non-adjuvant test. In the test, guinea pigs are exposed to a high dose of the substance.
In English, the term "guinea pig" is commonly used as a metaphor for a subject of scientific experimentation, or in modern times a subject of any experiment or test. This usage dates back to the early 20th century: the earliest examples cited by the Oxford English Dictionary date from 1913 and 1920. [ 182 ]
Currently, rodents are commonly used in animal testing for physiological, pathological and behavioral scientific studies, particularly mice and rats, but also guinea pigs, hamsters, gerbils and others. Mice are the most commonly used vertebrate species, due to their availability, size, low cost, ease of handling, and fast reproduction rate
According to the Humane Society of the United States, guinea pigs need a minimum of 7.5 square feet of space to thrive.If you've got the space, 10.5 square feet is your best bet and especially if ...
The murine local lymph node assay (LLNA) is an in vivo test for skin sensitisation.. LLNA has largely superseded the guinea pig maximisation test and the Buehler test.It is considered more scientific and less cruel (lower number of animals; less suffering) and has found broad scientific and regulatory acceptance.
From the common American guinea pig to the exotic Lunkarya Guinea Pig, these are the guinea pig breeds you should know about.
Human subject research is systematic, scientific investigation that can be either interventional (a "trial") or observational (no "test article") and involves human beings as research subjects, commonly known as test subjects. Human subject research can be either medical (clinical) research or non-medical (e.g., social science) research. [1]