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Cholera (/ ˈ k ɒ l ər ə /) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. [4] [3] Symptoms may range from none, to mild, to severe. [3]The classic symptom is large amounts of watery diarrhea lasting a few days. [2]
A cholera vaccine is a vaccine that is effective at reducing the risk of contracting cholera. [10] The recommended cholera vaccines are administered orally to elicit local immune responses in the gut, where the intestinal cells produce antibodies against Vibrio cholerae, the bacteria responsible for the illness. This immune response was poorly ...
Cholera toxin mechanism. Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [1] [2] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [3] It is a member of the heat-labile enterotoxin family.
Cholera infections are most commonly acquired from drinking water in which V. cholerae is found naturally or into which it has been introduced from the feces of an infected person. Cholera is most likely to be found and spread in places with inadequate water treatment, poor sanitation, and inadequate hygiene.
Treatment of a cholera infection consists of replenishing lost fluid and electrolytes by intravenous or oral solutions, and by antibiotics. [2] El Tor outbreaks can be prevented by better standards of sanitation, filtering and boiling water, [ 4 ] thoroughly cooking seafood, and washing vegetables and fruits before consumption.
Vibrio vulnificus is a species of gram-negative, motile, curved rod-shaped (bacillus), pathogenic bacteria of the genus Vibrio.Present in marine environments such as estuaries, brackish ponds, or coastal areas, V. vulnificus is related to V. cholerae, the causative agent of cholera. [7]
Snow's work, particularly his maps of the Soho area cholera victims, convinced Whitehead that the Broad Street pump was the source of the local infections. Whitehead joined Snow in tracking the contamination to a faulty cesspool and the outbreak's index case (the baby with cholera).
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.