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A box model explaining the processes of toxicokinetics and toxicodynamics. While toxicokinetics describes the changes in the concentrations of a toxicant over time due to the uptake, biotransformation, distribution and elimination of toxicants, toxicodynamics involves the interactions of a toxicant with a biological target and the functional or structural alterations in a cell that can ...
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
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Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12]
Academic search engine - the topic is needed for the inclusion and exclusion of the articles listed in this article--222.67.215.118 09:58, 25 June 2009 (UTC) Actually I don't believe that Web of Science or Ovid are search engines; they are bibliographic databases.
Portal:Chemistry/Selected biography/10 Yuan Tseh Lee (born 1936) is a Taiwanese chemist, and the first Taiwanese-born Nobel Prize laureate. Along with John Charles Polanyi and Dudley R. Herschbach , he received the 1986 Nobel Prize in Chemistry "for their contributions to the dynamics of chemical elementary processes."
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If hydrogen cyanide is inhaled, it can cause a coma with seizures, apnea, and cardiac arrest, with death following in a matter of seconds.At lower doses, loss of consciousness may be preceded by general weakness, dizziness, headaches, vertigo, confusion, and perceived difficulty in breathing.