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Glucose uptake is the process by which glucose molecules are transported from the bloodstream into cells through specialized membrane proteins called glucose ...
The rate constant kel describes elimination pathways including clearance by the kidneys and uptake by the MPS, but does not include tumor accumulation. [ 13 ] PBPK models are compartmental models like many others, but they have a few advantages over so-called "classical" pharmacokinetic models, which are less grounded in physiology.
The first-line physiologic response to this demand is an increase in heart rate, breathing rate, and depth of breathing. Oxygen consumption (VO 2 ) during exercise is best described by the Fick Equation : VO 2 =Q x (a-vO 2 diff), which states that the amount of oxygen consumed is equal to cardiac output (Q) multiplied by the difference between ...
Pharmacokinetics: . Process of the uptake of drugs by the body, the biotransformation they undergo, the distribution of the drugs and their metabolites in the tissues, and the elimination of the drugs and their metabolites from the body over a period of time.
Insulin enhances glucose uptake and metabolism in the cells, thereby reducing blood sugar. Their neighboring alpha cells, by taking their cues from the beta cells, [10] secrete glucagon into the blood in the opposite manner: increased secretion when blood glucose is low, and decreased secretion when glucose concentrations are high.
V̇O 2 max (also maximal oxygen consumption, maximal oxygen uptake or maximal aerobic capacity) is the maximum rate of oxygen consumption attainable during physical exertion. [1] [2] The name is derived from three abbreviations: "V̇" for volume (the dot over the V indicates "per unit of time" in Newton's notation), "O 2" for oxygen, and "max" for maximum and usually normalized per kilogram of ...
A synapse during re-uptake. Note that some neurotransmitters are lost and not reabsorbed. Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
Uptake of extracellular molecules is also believed to be specifically mediated via receptors in caveolae. From left to right: Phagocytosis, Pinocytosis, Receptor-mediated endocytosis. Potocytosis is a form of receptor-mediated endocytosis that uses caveolae vesicles to bring molecules of various sizes into the cell. Unlike most endocytosis that ...