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In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11. [7] VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. [8] Glucocorticoids decrease VDR expression. [8] Many types of immune cells also express VDR ...
The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...
The VDR/RXR complex subsequently binds to vitamin D response elements (VDRE) which are specific DNA sequences adjacent to genes, numbers estimated as being in the thousands. The VDR/RXR/DNA complex recruits other proteins that transcribe the downstream gene into mRNA which in turn is translated into protein causing a change in cell function. [3 ...
All gene segments between the V β-D β-J β gene segments in the newly formed complex are deleted and the primary transcript is synthesized that incorporates the constant domain gene (V β-D β-J β-C β). mRNA transcription splices out any intervening sequence and allows translation of the full length protein for the TCR β-chain.
Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology , as well as single gene/single food compound relationships.
1576 n/a Ensembl ENSG00000160868 n/a UniProt P08684 n/a RefSeq (mRNA) NM_001202855 NM_001202856 NM_001202857 NM_017460 n/a RefSeq (protein) NP_001189784 NP_059488 n/a Location (UCSC) Chr 7: 99.76 – 99.78 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine ...
Vanessa Rissetto, R.D., is the co-founder of the virtual nutrition care service Culina Health. What is Red Dye No. 3? Red Dye No. 3 is an artificial food coloring derived from petroleum, ...
Nuclear receptors are specific to metazoans (animals) and are not found in protists, algae, fungi, or plants. [8] Amongst the early-branching animal lineages with sequenced genomes, two have been reported from the sponge Amphimedon queenslandica, two from the comb jelly Mnemiopsis leidyi [9] four from the placozoan Trichoplax adhaerens and 17 from the cnidarian Nematostella vectensis. [10]