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PP cells play an important role when it comes to the regulation of plasma glucose as they help to synthesize and release pancreatic polypeptide (PP). As PP cells secrete more pancreatic polypeptide, it has been shown to have a negative effect on insulin secretion giving it anorexic effects on intestinal functionality.
Immunohistochemistry for pancreatic polypeptide in a mouse pancreas, 200×. Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas.It is a hormone and it regulates pancreatic secretion activities, and also impacts liver glycogen storage and gastrointestinal secretion.
They give rise to both the endocrine and exocrine cells. Exocrine cells constitute the acinar cells and the ductal cells. The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide. [3]
Inhibits insulin secretion Galanin: Enteric nerves: Ghrelin: Stomach: Stimulates appetite, increases gastric emptying Glucagon-like peptide 1: Pancreas, ileum: Increases insulin secretion Glucagon-like peptide 2: Ileum, colon: Enterocyte-specific growth hormone Growth factors: Throughout the gut: Cell proliferation and differentiation Growth ...
There are about 1 million islets distributed throughout the pancreas of a healthy adult human. While islets vary in size, the average diameter is about 0.2 mm. [5]:928 Each islet is separated from the surrounding pancreatic tissue by a thin, fibrous, connective tissue capsule which is continuous with the fibrous connective tissue that is interwoven throughout the rest of the pancreas.
Incretins are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by a blood-glucose–dependent mechanism. [1] Some incretins also inhibit glucagon release from the alpha cells of the islets of Langerhans. In addition, they slow the rate of absorption of nutrients into the ...
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