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  2. Trimethoprim/sulfamethoxazole - Wikipedia

    en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole

    Its use is advised against in people being concomitantly treated with: [13] [3] [5] [6] [21] [22] ACE inhibitors like captopril , enalapril , lisinopril , perindopril , and ramipril due to the potential for additive hyperkalaemic effects [ 5 ]

  3. List of side effects of trimethoprim/sulfamethoxazole - Wikipedia

    en.wikipedia.org/wiki/List_of_side_effects_of...

    Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine

  4. Sulfamethoxazole - Wikipedia

    en.wikipedia.org/wiki/Sulfamethoxazole

    However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute. A half-life of 22–50 hours has been reported for people with creatinine clearances of less than 10 mL/minute. [11] Metabolism. Sulfamethoxazole is metabolized in the human liver to at least 5 metabolites.

  5. Brucellosis - Wikipedia

    en.wikipedia.org/wiki/Brucellosis

    Brucellosis [4] is a zoonosis caused by ingestion of unpasteurized milk from infected animals, or close contact with their secretions. [5] It is also known as undulant fever, Malta fever, and Mediterranean fever. [6] The bacteria causing this disease, Brucella, are small, Gram-negative, nonmotile, nonspore-forming, rod-shaped (coccobacilli ...

  6. Urinary anti-infective agent - Wikipedia

    en.wikipedia.org/wiki/Urinary_anti-infective_agent

    The use of TMP/SMX also raises concerns in patients with kidney disease. In patients with creatinine clearance less than 50 mL/min, the urine concentrations of SMX may decrease to subtherapeutic levels. Therefore, in patients with low creatinine clearance, it is recommended to prescribe a reduced dosage of TMP alone. [30]

  7. Minimum inhibitory concentration - Wikipedia

    en.wikipedia.org/wiki/Minimum_inhibitory...

    The value obtained is largely dependent on the susceptibility of the microorganism and the antimicrobial potency of the chemical, but other variables can affect results too. [5] The MIC is often expressed in micrograms per milliliter (μg/mL) or milligrams per liter (mg/L).

  8. Dose (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Dose_(biochemistry)

    In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...

  9. Hook effect - Wikipedia

    en.wikipedia.org/wiki/Hook_effect

    Simple illustration of the effects of excess antigen and dosage response curve. Examples include high levels of syphilis antibodies in HIV patients or high levels of cryptococcal antigen leading to false negative tests in undiluted samples. [7] [8] This phenomenon is also seen in serological tests for Brucellosis.

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