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  2. Adenosine - Wikipedia

    en.wikipedia.org/wiki/Adenosine

    Adenosine is a key factor in regulating the body's sleep-wake cycle. [39] Adenosine levels rise during periods of wakefulness and lowers during sleep. Higher adenosine levels correlate with a stronger feeling of sleepiness, also known as sleep drive or sleep pressure. [40]

  3. Neuroscience of sleep - Wikipedia

    en.wikipedia.org/wiki/Neuroscience_of_sleep

    Although the exact nature of sleep drive is unknown, homeostatic pressure builds up during wakefulness and this continues until the person goes to sleep. Adenosine is thought to play a critical role in this and many people have proposed that the pressure build-up is partially due to adenosine accumulation. However, some researchers have shown ...

  4. Central nervous system fatigue - Wikipedia

    en.wikipedia.org/wiki/Central_Nervous_System_Fatigue

    Central nervous system fatigue, or central fatigue, is a form of fatigue that is associated with changes in the synaptic concentration of neurotransmitters within the central nervous system (CNS; including the brain and spinal cord) which affects exercise performance and muscle function and cannot be explained by peripheral factors that affect muscle function.

  5. Adenosine monophosphate deaminase deficiency type 1

    en.wikipedia.org/wiki/Adenosine_monophosphate...

    Fatigue and sedation after heavy exertion can be caused by excess adenosine in the cells which signals muscle fiber to feel fatigued. In the brain, excess adenosine decreases alertness and causes sleepiness. In this way, adenosine may play a role in fatigue from MADD. [4] Recovery from over-exertion can be hours, days or even months.

  6. What Doctors Want You to Know About Coffee’s Health Benefits

    www.aol.com/doctors-want-know-coffee-health...

    What does coffee do to your body? When you drink coffee, Dr. Wu says the caffeine acts as a stimulant by blocking adenosine, the neurotransmitter that promotes sleep, resulting in increased ...

  7. Sleep - Wikipedia

    en.wikipedia.org/wiki/Sleep

    Adenosine levels increase in the cortex and basal forebrain during prolonged wakefulness, and decrease during the sleep-recovery period, potentially acting as a homeostatic regulator of sleep. [42] [43] Coffee, tea, and other sources of caffeine temporarily block the effect of adenosine, prolong sleep latency, and reduce total sleep time and ...

  8. Sleep inertia - Wikipedia

    en.wikipedia.org/wiki/Sleep_inertia

    Prior sleep deprivation increases the percentage of time spent in slow-wave sleep (SWS). Therefore, an individual who was previously sleep deprived will have a greater chance of experiencing sleep inertia. [4] [7] Adenosine levels in the brain progressively increase with sleep deprivation, and return to normal during sleep. Upon awakening with ...

  9. How Much Weight Can I Safely Lose in Just a Week? - AOL

    www.aol.com/much-weight-safely-lose-just...

    Researchers think it suppresses appetite by increasing the amount of GLP-1 hormone your body produces. One review found that those who took 2.55 grams of metformin a day lost about 13 pounds over ...