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There is no vaccine against hepatitis C. [1] [9] Prevention includes harm reduction efforts among people who inject drugs, testing donated blood, and treatment of people with chronic infection. [4] [10] Chronic infection can be cured more than 95% of the time with antiviral medications such as sofosbuvir or simeprevir.
Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. [1] After completing Phase III clinical trials, on February 10, 2014, Gilead filed for U.S. approval of a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. [2] [3] The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication ...
Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. [8] It is a fixed-dose combination of ledipasvir and sofosbuvir. [8] Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. [9] Some evidence also supports use in HCV genotype 3 and 4. [9]
In all cases, after just 12 weeks of treatment, 95 percent of people diagnosed with hepatitis C are cured. How to Prevent Hepatitis C Cured of hepatitis C, however, doesn’t mean immune.
In the European Union it was approved in July 2016, for the treatment of chronic hepatitis C virus infection in adults. [7] The safety and efficacy of sofosbuvir/velpatasvir for a 12-week treatment was evaluated in three Phase III clinical trials of 1,558 subjects without cirrhosis or with compensated cirrhosis (mild cirrhosis). [13]
For example, for the treatment of genotypes 1, 4, 5, and 6 hepatitis C infections, sofosbuvir can be used in combination with the viral NS5A inhibitor ledipasvir. [16] In genotype 2 and 3 HCV infections, sofosbuvir can be used in combination with daclatasvir. For the treatment of cases with cirrhosis or liver transplant patients, weight-based ...
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