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Thermal nociceptors are activated by noxious heat or cold at various temperatures. There are specific nociceptor transducers that are responsible for how and if the specific nerve ending responds to the thermal stimulus. The first to be discovered was TRPV1, and it has a threshold that coincides with the heat pain temperature of 43 °C.
In nociception, intense chemical (e.g., capsaicin present in chili pepper or cayenne pepper), mechanical (e.g., cutting, crushing), or thermal (heat and cold) stimulation of sensory neurons called nociceptors produces a signal that travels along a chain of nerve fibers via the spinal cord to the brain. [1]
Thermoreceptors of the skin sense the temperature of water. A thermoreceptor is a non-specialised sense receptor, or more accurately the receptive portion of a sensory neuron, that codes absolute and relative changes in temperature, primarily within the innocuous range.
Thermal nociceptors are activated by noxious heat or cold at various temperatures. Mechanical nociceptors respond to excess pressure or mechanical deformation. Chemical nociceptors respond to a wide variety of chemicals, some of which are signs of tissue damage. They are involved in the detection of some spices in food.
One significant limitation of thermal assays lies in the specificity and validity of results in animals as models of human pain. [2] Very little is known about the functional mechanics of nociceptive afferents in murine subjects, thus the translation of any pain response observed from these animals to humans is questionable.
Thermal nociceptors are activated by noxious heat or cold at various temperatures. [24] Mechanical nociceptors respond to excess pressure or mechanical deformation, such as a pinch. [24] Chemical nociceptors respond to a wide variety of chemicals, some of which signal a response.
Edward Roy Perl (October 6, 1926 – July 15, 2014) was an American neuroscientist whose research focused on neural mechanisms of and circuitry involved in somatic sensation, principally nociception.
In physiology, thermoception or thermoreception is the sensation and perception of temperature, or more accurately, temperature differences inferred from heat flux.It deals with a series of events and processes required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal in order to trigger an appropriate response.