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Squalene is an organic compound. It is a triterpene with the formula C 30 H 50. It is a colourless oil, although impure samples appear yellow. It was originally obtained from shark liver oil (hence its name, as Squalus is a genus of sharks). An estimated 12% of bodily squalene in humans is found in sebum. [5]
AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix. It is also in Arepanrix and the Q-pan for H5N1 influenza. [1] A dose of AS03 adjuvant contains [2] 10.69 mg squalene
Squalene is also produced by the human liver as a precursor to cholesterol and is present in human sebum. [22] MF59 is an oil-in-water emulsion of squalene adjuvant used in some human vaccines. As of 2021, over 22 million doses of one vaccine with squalene, FLUAD, have been administered with no severe adverse effects reported. [23]
The growth of this segment is primarily due to the use of squalene in a wide range of cosmetic products including skin care and hair care. Many global cosmetic companies such as L’Oréal, Unilever and St. Petersburg are responsible for the use of squalene. Botanica has begun to transition from shark liver oil-squalene based to plant-based ...
A principal component of many shark oils is squalene, a triterpenoid (C 30 H 50), ranging up to 90% of the oil, depending on the species. In Centrophorus species squalene may account for 15% of the total body weight. Pristane, another terpenoid (C 19 H 40), is often a minor component, ranging up to nearly 8% of the oil. [12]
Squalene and the more widely available squalane can moisturize skin and soothe redness. Find it in products from top brands like Biossance, The Ordinary, Kieh’s and more. Why you should add ...