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Ankylosing spondylitis (AS) is a systemic rheumatic disease, meaning it affects the entire body. 1–2% of individuals with the HLA-B27 genotype develop the disease. [17] Tumor necrosis factor-alpha (TNF α) and interleukin 1 (IL-1) are also implicated in ankylosing spondylitis.
People with ankylosing spondylitis experience up to 50% more sick leave episodes, an overall 8% loss of productivity, and a thrice higher rate of disability than the general population. Their overall frequency of disability and economic costs are comparable to those of rheumatoid arthritis. [48] Furthermore, increasing evidence indicates that ...
Joint pain is an important symptom, although some children experience minimal or no pain with their arthritis. [7] In these children, the first sign of arthritis may be limping, especially in the morning. [7] Young children are often very good at changing how they move when they have joint pain: they learn to move so that it does not hurt.
The term itself is an umbrella term characterizing a diverse disease family united by shared clinical and genetic features, such as the involvement of the axial skeleton. [2] The 2009 introduced term axial spondyloarthritis is a preferred term nowadays and substitutes the old term ankylosing spondylitis. [3]
Ankylosing spondylitis (AS) is a form of arthritis that primarily affects the spine, although other joints can become involved. It causes inflammation of the spinal joints (vertebrae) that can lead to severe, chronic pain and discomfort.
The 31-year-old frontman of the Grammy-winning band is also campaigning to bring awareness to the painful and hidden disease that is ankylosing spondylitis (AS), which he was diagnosed with in his ...
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