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Ciclosporin is indicated to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants. [8] [7] It is also approved in the US for treating of rheumatoid arthritis and psoriasis, persistent nummular keratitis following adenoviral keratoconjunctivitis, [25] [7] and as eye drops for treating dry eyes caused by ...
Side effects include burning sensation (common), [4] redness, discharge, watery eyes, eye pain, foreign body sensation, itching, stinging, and blurred vision. [14] [4] Long term use of ciclosporin at high doses is associated with an increased risk of cancer. [48] [49] Cheaper generic alternatives are available in some countries. [50]
Eye drops have less of a risk of side effects than do oral medicines, and such risk can be minimized by occluding the lacrimal punctum (i.e. pressing on the inner corner of the eye) for a short while after instilling drops.
In one study, 10 people were given two drops of 0.5 mg/mL of tetryzoline eye drops (0.025–0.05 mg) at 0 hrs, 4 hrs, 8 hrs, and 12 hrs. Within a 24-hour time window, since the last dose of tetryzoline, the blood serum concentration of tetryzoline in the test subjects was 0.068-0.380 ng /mL and the urine concentration was 13–210 ng/mL.
Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid action in reducing swelling when applied to mucous membranes . It is a sympathomimetic agent with marked alpha adrenergic activity that acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction ...
Visine (/ ˌ v aɪ ˈ z iː n /), also known as Vispring, is a brand of eye drops produced by Kenvue. [1] Visine was first introduced in 1958 and was acquired by Pfizer in 1999. [2] [3] In 2006, Johnson & Johnson acquired Visine, along with Pfizer's entire consumer healthcare portfolio. [4]
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