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Because malate dehydrogenase is closely tied to the citric acid cycle, studies have proposed and experimentally demonstrated that citrate is an allosteric regulator of malate dehydrogenase depending on the concentrations of L-malate and NAD +. This may be due to deviations observed in the kinetic behavior of malate dehydrogenase at high ...
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. [ 5 ] Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate , utilizing the NAD/NADH cofactor system in the citric acid cycle.
Malate dehydrogenase is present in two forms in the shuttle system: mitochondrial malate dehydrogenase and cytosolic malate dehydrogenase. The two malate dehydrogenases are differentiated by their location and structure, and catalyze their reactions in opposite directions in this process. First, in the cytosol, malate dehydrogenase catalyses ...
(S)-malate + NAD(P) + oxaloacetate + NAD(P)H + H + This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum , catalyses only the reduction of oxaloacetate , and can use NAD + and NADP + with similar specific activity.
Malate is oxidized to pyruvate and CO 2, and NADP + is reduced to NADPH. This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is (S)-malate:NADP + oxidoreductase (oxaloacetate-decarboxylating).
Citrate ion Malate ion. The citrate-malate shuttle is a series of chemical reactions, commonly referred to as a biochemical cycle or system, that transports acetyl-CoA in the mitochondrial matrix across the inner and outer mitochondrial membranes for fatty acid synthesis. [1] Mitochondria are enclosed in a double membrane.
In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (EC 1.1.1.38) is an enzyme that catalyzes the chemical reaction below (S)-malate + NAD + pyruvate + CO 2 + NADH. Thus, the two substrates of this enzyme are (S)-malate and NAD +, whereas its 3 products are pyruvate, CO 2, and NADH.