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Hemolytic–uremic syndrome (HUS) is a group of blood disorders characterized by low red blood cells, acute kidney injury (previously called acute renal failure), and low platelets. [ 1 ] [ 3 ] Initial symptoms typically include bloody diarrhea , fever , vomiting , and weakness.
Atypical hemolytic uremic syndrome (aHUS), also known as complement-mediated hemolytic uremic syndrome (not to be confused with hemolytic–uremic syndrome), is an extremely rare, life-threatening, progressive disease that frequently has a genetic component. In most cases, it can be effectively controlled by interruption of the complement cascade.
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
According to an update from the CDC on Friday, Oct. 25, of the 22 people who have been hospitalized in relation to the outbreak, one is a "child with complications of hemolytic uremic syndrome (HUS)."
TTP is a form of thrombotic microangiopathy (TMA), [37] the formation of blood clots in small blood vessels throughout the body, which can lead to microangiopathic hemolytic anemia and thrombocytopenia. [37] This characteristic is shared by two related syndromes, hemolytic-uremic syndrome (HUS) and atypical hemolytic uremic syndrome (aHUS). [4]
Over half of the victims were hospitalized, and 13 developed hemolytic uremic syndrome (HUS), a life-threatening condition that can cause kidney failure. Wendy’s responded by removing romaine ...
The European Medicines Agency approved it for the treatment of paroxysmal nocturnal hemoglobinuria in June 2007, [7] and in November 2011, for the treatment of atypical hemolytic uremic syndrome. [24] Health Canada approved it in 2009, to treat paroxysmal nocturnal hemoglobinuria and in 2013, as the only drug to treat atypical hemolytic uremic ...
Two people also developed hemolytic uremic syndrome, a serious condition that can cause kidney failure. Health officials say there have been likely more sickened in the outbreak and McDonald's ...