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Lung cancer is the most diagnosed and deadliest cancer worldwide, with 2.2 million cases in 2020 resulting in 1.8 million deaths. [3] Lung cancer is rare in those younger than 40; the average age at diagnosis is 70 years, and the average age at death 72. [2] Incidence and outcomes vary widely across the world, depending on patterns of tobacco use.
The first cause of cancer was identified by British surgeon Percivall Pott, who discovered in 1775 that cancer of the scrotum was a common disease among chimney sweeps. [ citation needed ] The work of other individual physicians led to various insights, but when physicians started working together they could draw firmer conclusions.
This means that a person living in an average European dwelling with 50 Bq/m 3 has a lifetime excess lung cancer risk of 1.5–3 × 10 −3. Similarly, a person living in a dwelling with a high radon concentration of 1000 Bq/m 3 has a lifetime excess lung cancer risk of 3–6%, implying a doubling of background lung cancer risk. [63]
Radon has been considered the second leading cause of lung cancer in the United States and leading environmental cause of cancer mortality by the EPA, [145] with the first one being smoking. [146] Others have reached similar conclusions for the United Kingdom [ 135 ] and France. [ 147 ]
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). NSCLC accounts for about 85% of all lung cancers. [1] [2] [3] As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small-cell carcinoma.
The incidence of lung cancer is highly correlated with smoking. Tobacco smoking is associated with many forms of cancer, [20] and causes 80% of lung cancer. [21] Decades of research has demonstrated the link between tobacco use and cancer in the lung, larynx, head, neck, stomach, bladder, kidney, esophagus and pancreas. [22]