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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
A 2016 Science paper reports that the trapezoid rule was in use in Babylon before 50 BCE for integrating the velocity of Jupiter along the ecliptic. [1]In 1994, a paper titled "A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" was published, only to be met with widespread criticism for rediscovering the Trapezoidal Rule and coining it ...
In qualitative terms, a line integral in vector calculus can be thought of as a measure of the total effect of a given tensor field along a given curve. For example, the line integral over a scalar field (rank 0 tensor) can be interpreted as the area under the field carved out by a particular curve.
Integration, the process of computing an integral, is one of the two fundamental operations of calculus, [a] the other being differentiation. Integration was initially used to solve problems in mathematics and physics, such as finding the area under a curve, or determining displacement from velocity. Usage of integration expanded to a wide ...
The term "quadrature" is a traditional term for area; the integral is geometrically interpreted as the area under the curve y = x n. Traditionally important cases are y = x 2 , the quadrature of the parabola , known in antiquity, and y = 1/ x , the quadrature of the hyperbola , whose value is a logarithm .
Numerical integration has roots in the geometrical problem of finding a square with the same area as a given plane figure (quadrature or squaring), as in the quadrature of the circle. The term is also sometimes used to describe the numerical solution of differential equations .
The integral as the area of a region under a curve. A sequence of Riemann sums over a regular partition of an interval. The number on top is the total area of the rectangles, which converges to the integral of the function. The partition does not need to be regular, as shown here.
Simpson's rules are a set of rules used in ship stability and naval architecture, to calculate the areas and volumes of irregular figures. [1] This is an application of Simpson's rule for finding the values of an integral, here interpreted as the area under a curve.