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On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
[99] [100] At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. [100] [99] There is a similar thought process with using high-dose atorvastatin as a form of secondary thrombotic stroke recurrence ...
A cerebroprotectant (formerly known as a neuroprotectant) is a drug that is intended to protect the brain after the onset of acute ischemic stroke. [1] As stroke is the second largest cause of death worldwide and a leading cause of adult disability, over 150 drugs have been tested in clinical trials to provide cerebroprotection.
The researchers discovered that people who had high fluctuations in their cholesterol levels had a 60 percent higher risk of developing dementia and a 23 percent greater risk of cognitive decline.
Stroke. Cardiovascular disease. Heart failure. Heart attack. ... These include sleep apnea, diabetes, high cholesterol, thyroid problems, and chronic kidney disease. ... and it may take a while to ...
The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP). JUPITER was the first clinical trial to indicate that statin therapy may provide benefit to patients with low-to-normal LDL levels and no known cardiovascular disease.