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It contains clindamycin, as the phosphate, a lincosamide antibacterial; adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent. [2] It is applied to the skin . [ 2 ]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
[9] [10] An adapalene/benzoyl peroxide combination medication is also available. Furthermore, adapalene, like other retinoids, increases the efficacy and penetration of other topical acne medications that are used in conjunction with topical retinoids as well as hastens the improvement of the postinflammatory hyperpigmentation caused by acne. [9]
Concentration: The strength of your over-the-counter benzoyl peroxide will range from 2.5% to 10%. The strength you use will depend on your skin type and its tolerance. The strength you use will ...
Differin gel is an NBC Select staff favorite and Wellness Award winner for best acne treatment — it contains 0.1% adapalene, which is an over-the-counter retinoid often used to treat acne ...
The combination of the 10% benzoyl peroxide and light results in more than 50% degradation of tretinoin in about 2 hours and 95% in 24 hours. [34] This lack of stability in the presence of light and oxidizing agents has led to the development of novel formulations of the drug.