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Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). [ 1 ] PDT is used in treating acne , wet age-related macular degeneration , psoriasis , and herpes .
Schematic representation of the mechanism of (a) photopharmacology (b) photodynamic therapy, and (c) optogenetics. The discovery of natural photoreceptors such as rhodopsins in the eye inspired the biomedical and pharmacology research community to engineer light-sensitive proteins for therapeutic applications. [2]
Laser radiation being delivered via a fiber for photodynamic therapy to treat cancer. A 40-watt CO 2 laser with applications in ENT, gynecology, dermatology, oral surgery, and podiatry. Laser medicine is the use of lasers in medical diagnosis, treatments, or therapies, such as laser photodynamic therapy, [1] photorejuvenation, and laser surgery.
Central serous chorioretinopathy (CSC or CSCR), also known as central serous retinopathy (CSR), is an eye disease that causes visual impairment, often temporary, usually in one eye. [ 1 ] [ 2 ] When the disorder is active it is characterized by leakage of fluid under the retina that has a propensity to accumulate under the central macula.
Photodynamic therapy: PK Penetrating keratoplasy: POAG Primary open-angle glaucoma PPDR Preproliferative diabetic retinopathy PRA Pan-retinal ablation PRK Photorefractive keratectomy PRP Pan-retinal photocoagulation PSCC Posterior sub-capsular cataract PVD Posterior vitreous detachment PXF Pseudoexfoliative syndrome RD Retinal detachment: RK
Dental infections tend to also respond better to photothermal therapy than photodynamic therapy, though both have a strong effect. [ 10 ] [ 11 ] [ 12 ] The efficacy of PDT for antimicrobial usage is limited by the properties of the membrane of the target cell such as the electrical gradient ( membrane potential ) and lipid composition.
The photodynamic process is predominantly a noninvasive technique wherein the photosensitizers are put inside a patient so that it may accumulate on the tumor or cancer. When the photosensitizer reaches the tumor or cancer, wavelength specific light is shined on the outside of the patient's affected area.
Photodynamic therapy (PDT) is a form of phototherapy using nontoxic light-sensitive compounds (photosensitizers) that are exposed selectively to light at a controlled wavelength, laser intensity, and irradiation time, whereupon they generate toxic reactive oxygen species (ROS) that target malignant and other diseased cells.