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4-Androstene-3,6,17-trione (4-AT; also marketed as 6-OXO or 4-etioallocholen-3,6,17-trione) is a drug or nutritional supplement that may increase the testosterone-estrogen ratio, but has no proven effect on body composition. Its use can be detected in urine.
Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1 , a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis .
GnRH modulators affect the secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn affects the gonads, influencing their function and hence fertility as well as the production of sex steroids, including that of estradiol and progesterone in women and of testosterone in men.
An example of a rapid, non-invasive, sweat-based drug test is fingerprint drug screening. [48] This 10 minute fingerprint test [ 49 ] is in use by a variety of organisations in the UK and beyond, including within workplaces, [ 50 ] [ 51 ] drug treatment and family safeguarding services [ 52 ] [ 53 ] at airport border control (to detect drug ...
FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor. [6] The sugar portion of the hormone is covalently bonded to asparagine , and is composed of N-acetylgalactosamine , mannose , N-acetylglucosamine , galactose , and ...
Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
Macroorchidism is related to IGFS1 deficiency, which causes an increase in the secretion of follicle stimulating hormone (FSH). There are other causes for macroorchidism, such as hypothyroidism, local tumors, and aromatase deficiency. [3] Macroorchidism can be diagnosed by measuring the testicular volume using a prader orchidometer. [4]
An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This results in an inhibition of the hypothalamic-pituitary-gonadal (HPG) axis , and thus a decrease in the levels of the androgen , estrogen , and ...