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[21] [22] [23] Moreover, high-potency glucocorticoid should be applied to skin only once a day and should not be used for more than fourteen days. [24] Even low-potency topical glucocorticoids are able to cause adverse effects in children when used for prolonged periods of time.
Hydrocortisone aceponate is a veterinary corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions). [6] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid .
The strength of topical hydrocortisone products ranges from 0.1% to 2.5%, which means there could be 1 mg to 25 mg hydrocortisone in 1g of the products. [12] Some formulations for topical hydrocortisone include hydrocortisone 0.5% cream or ointment, hydrocortisone 1% cream or ointment, and hydrocortisone 2.5% cream or ointment. [34]
Some recommend using the topical steroid for 3 consecutive days on, followed by 4 consecutive days off. [10] Long-term use of topical steroids can lead to secondary infection with fungus or bacteria (see tinea incognito ), skin atrophy, telangiectasia (prominent blood vessels), skin bruising and fragility.
Pyrethrin based flea treatments meant for dogs can be hazardous to cats. Flea and tick ointment is also hazardous to humans. If the product comes into contact with human skin, it is recommended to wash thoroughly with soap and water. [3]
The equivalent doses and relative potencies of hydrocortisone compared to various other synthetic corticosteroids have also been reviewed and summarized. [13] The endogenous production rate of cortisol is approximately 5.7 to 9.9 mg/m 2 per day, which corresponds to an oral hydrocortisone dose of approximately 15 to 20 mg/day (for a 70-kg person).
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