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The virus was not discovered until 1966 when Baruch Blumberg, then working at the National Institutes of Health (NIH), discovered the Australia antigen (later known to be hepatitis B surface antigen, or HBsAg) in the blood of Aboriginal Australian people. [128]
HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]
Hepatitis B vaccine is a vaccine that prevents hepatitis B. [13] ... the important first step, and later discovered the way to make the first hepatitis B vaccine ...
Baruch Samuel Blumberg (July 28, 1925 – April 5, 2011), known as Barry Blumberg, was an American physician, geneticist, and co-recipient of the 1976 Nobel Prize in Physiology or Medicine (with Daniel Carleton Gajdusek), for his work on the hepatitis B virus while an investigator at the NIH and at the Fox Chase Cancer Center. [3]
It was discovered to be part of the virus that caused serum hepatitis by virologist Alfred Prince in 1968. Heptavax, a "first-generation" hepatitis B vaccine in the 1980s, was made from HBsAg extracted from the blood plasma of hepatitis patients. More modern vaccines are made from recombinant HBsAg grown in yeast.
In 1989, investigators from the CDC (Daniel W. Bradley) and Chiron (Michael Houghton) identified the hepatitis C virus, which had previously been known as non-A, non-B hepatitis and could not be detected in the blood supply. [12] Only in 1992 was a blood test created that could detect hepatitis C in donated blood. [12]
Nobel Prize in Physiology or Medicine 2020: Seminal experiments by HJ Alter, M Houghton and CM Rice leading to the discovery of HCV as the causative agent of non-A, non-B hepatitis. As a young research fellow in 1964, Alter co-discovered the Australia antigen with Baruch Blumberg. [14] This work was a major factor in isolating the hepatitis B ...
Pablo Valenzuela (Latin American Spanish: [ˈpaβlo βalenˈswela]; born June 13, 1941) is a Chilean biochemist dedicated to biotechnology development. [2] He is known for his genetic studies of hepatitis viruses; participated as R&D Director in the discovery of hepatitis C virus and the invention of the world's first recombinant vaccine (against hepatitis B virus).