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L-serine-phosphatidylethanolamine phosphatidyltransferase (EC 2.7.8.29, phosphatidylserine synthase 2, serine-exchange enzyme II, PTDSS2 (gene)) is an enzyme with systematic name L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase. [1] [2] This enzyme catalyses the following chemical reaction
Phosphatidylserine (PS) is the major acidic phospholipid class that accounts for 13–15% of the phospholipids in the human cerebral cortex. [7] In the plasma membrane, PS is localized exclusively in the cytoplasmic leaflet where it forms part of protein docking sites necessary for the activation of several key signaling pathways.
19210 Ensembl ENSG00000156471 ENSMUSG00000021518 UniProt P48651 Q99LH2 RefSeq (mRNA) NM_014754 NM_001290225 NM_008959 RefSeq (protein) NP_001277154 NP_055569 NP_032985 Location (UCSC) Chr 8: 96.26 – 96.34 Mb Chr 13: 67.08 – 67.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphatidylserine synthase 1 is a protein that in humans is encoded by the PTDSS1 gene. Function The ...
The conversion of PA into diacylglycerol (DAG) by LPPs is the commitment step for the production of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS). In addition, DAG is also converted into CDP-DAG, which is a precursor for phosphatidylglycerol (PG), phosphatidylinositol (PI) and phosphoinositides (PIP, PIP 2 ...
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation pathway is the main source of synthesis for phosphatidylethanolamine in the membranes of the mitochondria. Phosphatidylethanolamine produced in the mitochondrial membrane is also ...
A lysophosphatidylserine is a lysophospholipid.Various lysophosphatidylserines trigger TLR 2. [1] They can also modulate T cell function via suppression of Interleukin_2 (IL-2) production in CD4 T cells. [2]
Phosphatidylserine is translocated to the exoplasmic leaflet by the activation of scramblases, leading to pro-coagulant properties and providing a phagocytic signal to the macrophages that engulf and clear the apoptotic cells. The involvement of other associated proteins aiding scrambling activity cannot be ruled out.
Biosynthesis, i.e., chemical synthesis occurring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex ...