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15277 Ensembl ENSG00000159399 ENSMUSG00000000628 UniProt P52789 O08528 RefSeq (mRNA) NM_000189 NM_001371525 NM_013820 RefSeq (protein) NP_000180 NP_001358454 NP_038848 Location (UCSC) Chr 2: 74.83 – 74.89 Mb Chr 6: 82.7 – 82.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hexokinase II, also known as Hexokinase B and HK2, is an enzyme which in humans is encoded by the HK2 gene ...
It is the hexokinase found in muscle and heart. Hexokinase II is also located at the mitochondria outer membrane so it can have direct access to ATP. [7] The relative specific activity of hexokinase II increases with pH at least in a pH range from 6.9 to 8.5. [8] Hexokinase III/C is substrate-inhibited by glucose at physiological concentrations.
The polyol metabolic pathway. [6]Cells use glucose for energy.This normally occurs by phosphorylation from the enzyme hexokinase. However, if large amounts of glucose are present (as in diabetes mellitus), hexokinase becomes saturated and the excess glucose enters the polyol pathway when aldose reductase reduces it to sorbitol.
In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule donates a phosphate group to the substrate molecule.
A recent review shows who newer medications for type 2 diabetes may help the most, particularly in reducing the risk of cardiovascular disease. Whose cardiovascular health do SGLT2, GLP-1 diabetes ...
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location [1] [2] of this key enzyme of glucose metabolism. [3] GKRP is a 68 kD protein of 626 amino acids.
Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of ...
Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. [ 5 ] [ 6 ] Hexokinases phosphorylate glucose to produce glucose-6-phosphate , the first step in most glucose metabolism pathways.