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The outbreak of influenza reported in 1173 is not considered to be a pandemic, and other reports to 1500 generally lack reliability. 16th century The 1510 influenza pandemic spread from Asia to Africa, then engulfing Europe. It is the first documented case of intercontinental spread of an influenza virus, with less lethality than future pandemics.
In December 2008, research by Yoshihiro Kawaoka of the University of Wisconsin linked the presence of three specific genes (termed PA, PB1, and PB2) and a nucleoprotein derived from Spanish flu samples to the ability of the 1918 flu virus to invade the lungs and cause pneumonia. These genes were inserted into a modern H1N1 strain and triggered ...
1918 Flu: Influenza A/H1N1: 17–100 million 1–5.4% of global population [4] 1918–1920 Worldwide 2 Plague of Justinian: Bubonic plague 15–100 million 25–60% of European population [5] 541–549 North Africa, Europe, and Western Asia 3 HIV/AIDS pandemic: HIV/AIDS: 44 million (as of 2025) – 1981–present [6] Worldwide 4 Black Death ...
In 1918, the world's population was menaced by a virus now known as influenza. The "flu," for short, has become a commonality that is widely misunderstood, even a century after it claimed 50 ...
The 1918 flu pandemic, commonly referred to as the Spanish flu, was a category 5 influenza pandemic caused by an unusually severe and deadly Influenza A virus strain of subtype H1N1. The difference between the influenza mortality age-distributions of the 1918 epidemic and normal epidemics.
Flu. Symptoms. Sore throat, runny or stuffy nose and cough are all symptoms that the flu (aka influenza) shares with other respiratory viruses. ... there were 200 pediatric deaths related to flu ...
For the 1918 flu, people infected numbers (500 million), mortality rate (2~3%) contradict the deaths worldwide "20–100 million" statements. Review needed. Lead: Johnson NPAS, Mueller (2002). "Updating the Accounts: Global Mortality of the 1918–1920 Spanish Influenza Pandemic". Kilbourne ED (January 2006). "Influenza pandemics of the 20th ...
The 1967–1968 flu season was the last to be dominated by H2N2 before the emergence of H3N2 in 1968 and the consequent "Hong Kong flu" pandemic that lasted until 1970. This season was particularly severe in England and France, in which pneumonia and influenza excess mortality was two to three times greater than in other countries. [ 54 ]