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Venlafaxine was approved for medical use in the United States in 1993. [9] It is available as a generic medication. [9] In 2022, it was the 44th most commonly prescribed medication in the United States, with more than 13 million prescriptions. [13] [14]
At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission. [22] At small doses, venlafaxine has also been shown to be effective in treating vasomotor symptoms (hot flashes and night sweats) of menopause.
Ejaculation disorder — sexual side effects can be seen with virtually any antidepressant, especially those that inhibit the reuptake of serotonin (including venlafaxine). [4] Somnolence; Dry mouth; Sweating; Withdrawal
Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar. [18]
Selective serotonin reuptake inhibitors, or serotonin-specific re-uptake inhibitor (SSRIs), are a class of chemical compounds that have application as antidepressants and in the treatment of depression and other psychiatric disorders.
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).
In 2022, it was the 149th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [ 12 ] [ 13 ] Phentermine was withdrawn from the market in the United Kingdom in 2000, while the combination medication fen-phen , of which it was a part, was withdrawn from the market in 1997 due to side effects of ...
It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300–450 mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600 mg. [10] [11] For comparison, the incidence of unprovoked seizure in the general population is 0.07–0.09%, and the risk of ...