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Testosterone levels in males and females Total testosterone Stage Age range Male Female Values ... 1.0–8.3 pg/mL: 3.5–28.8 pmol/L Adult: ≥18 years: 44–244 pg/mL:
The oral bioavailability of testosterone in young women after a single 25 mg dose was found to be 3.6 ± 2.5%. [29] High levels of testosterone are also achieved with a 60 mg dose of oral testosterone in men with liver cirrhosis. [2]
Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: a = Mostly discontinued or unavailable.
Oral conjugated estrogens at a dosage of 7.5 mg/day has been found to suppress total testosterone levels in men to an equivalent extent as 3 mg/day oral diethylstilbestrol, which is the minimum dosage of diethylstilbestrol required to consistently suppress total testosterone levels into the castrate range (<50 ng/dL). [94]
The total endometrial proliferation dose of sublingual estradiol in women is 60 to 140 mg per cycle or 14 days and of sublingual estradiol benzoate in women is 60 to 180 mg per cycle or 14 days. [75]: 310 Both sublingual estradiol and sublingual estradiol benzoate have a persistence of estrogenic effect after a dose of only one day.
Estradiol levels after an intramuscular injection of 10 mg estradiol valerate in oil, Climacteron (150 mg testosterone enanthate, 1 mg estradiol benzoate, 7.5 mg estradiol dienanthate in oil), and control group in 20, 11, and 11 ovariectomized women, respectively. [128] Assays were performed using RIA. [128] Source was Sherwin et al. (1987). [128]
[citation needed] The estradiol produced by male humans, from testosterone, is present at serum levels roughly comparable to those of postmenopausal women (14–55 versus <35 pg/mL, respectively). [ citation needed ] It has also been reported that if concentrations of estradiol in a 70-year-old man are compared to those of a 70-year-old woman ...
However, free testosterone is difficult and expensive to measure (it requires a time-consuming dialysis step), and many laboratories do not offer this service. The free androgen index is intended to give a guide to the free testosterone level, but it is not very accurate (especially in males — see endocrine society commentary below).