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Valve interstitial cells (VIC), cardiac valve interstitial cells, or also known as valvular interstitial cells (VICs), are the most prevalent cells in the heart valve leaflets, which are a type of mesenchymal stem cells (MSCs) and are responsible for maintaining the extracellular matrix that provides the mechanical properties of the heart valve.
Interstitial fibrosis, which is unspecific, and has been described in congestive heart failure, hypertension, and normal aging. [2] Subepicardial fibrosis, also unspecific, and is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy. [3] [4] Replacement fibrosis, which indicates an older infarction. [2]
Gap junctions connect the cytoplasms of neighboring cells electrically allowing cardiac action potentials to spread between cardiac cells by permitting the passage of ions between cells, producing depolarization of the heart muscle. [3] [2] All of these junctions work together as a single unit called the area composita. [2]
Three-dimensional schematic of the interstitium, a fluid-filled space supported by a network of collagen. In anatomy, the interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell membrane or the skin, and internal structures, such as organs, including muscles and the circulatory system.
The myocytes of the heart (also called the myocardial fibers) are arranged in a general circumferential direction in the ventricles. In the left ventricle (LV), the fiber will change gradually in direction from a certain longitudinal-circumferential direction in the outer layer of the heart (epicardium) to another angulated direction almost orthogonal in the inner wall (endocardium), becoming ...
In crystallography, interstitial sites, holes or voids are the empty space that exists between the packing of atoms (spheres) in the crystal structure. [ citation needed ] The holes are easy to see if you try to pack circles together; no matter how close you get them or how you arrange them, you will have empty space in between.
Bachmann's bundle receives its blood supply from the sinoatrial nodal artery (right, left or both). [4]Besides Bachmann's bundle, the other three conduction tracts that constitute the atrial conduction system are known as the anterior, middle, and posterior tracts, which run from the sinoatrial node to the atrioventricular node, converging in the region near the coronary sinus.
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