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  2. Axicabtagene ciloleucel - Wikipedia

    en.wikipedia.org/wiki/Axicabtagene_ciloleucel

    Axicabtagene ciloleucel, sold under the brand name Yescarta, is a medication used for the treatment for large B-cell lymphoma that has failed conventional treatment. [8] T cells are removed from a person with lymphoma and genetically engineered to produce a specific T-cell receptor .

  3. FDA says cancer treatment CAR-T therapy may increase ... - AOL

    www.aol.com/news/fda-says-cancer-treatment-car...

    Since then, another five have been approved. The makers of the drugs — Bristol Myers Squibb, for Abecma and Breyanzi; Gilead Sciences' Kite Pharma, for Yescarta and Tecartus; Johnson & Johnson's ...

  4. Kite Pharma - Wikipedia

    en.wikipedia.org/wiki/Kite_Pharma

    Axicabtagene ciloleucel (KTE-C19, ZUMA-3, YESCARTA) was an investigational therapy (for the treatment of adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL)) in which a patient's T cells were genetically modified to express a chimeric antigen receptor designed to target the antigen CD19, a protein expressed on the cell surface of B-cell lymphomas and leukemias. [11]

  5. Gilead’s Kite Receives FDA Approval For Yescarta ... - AOL

    www.aol.com/news/gilead-kite-receives-fda...

    Kite, a unit of Gilead Sciences, announced that the US Food and Drug Administration (FDA) has approved its Yescarta T cell immunotherapy. The therapy is a first-of-its-kind treatment for adult ...

  6. US FDA seeks 'boxed warning' for CAR-T cancer therapies - AOL

    www.aol.com/news/us-fda-requires-boxed-warning...

    The FDA said in its letters to the companies on Monday that since the approval, it had identified adverse events and clinical trial reports describing T-cell malignancies.

  7. CAR T cell - Wikipedia

    en.wikipedia.org/wiki/CAR_T_cell

    These trials ultimately led in the US to the FDA's first two approvals of CAR T cells in 2017, those for tisagenlecleucel (Kymriah), marketed by Novartis originally for B-cell precursor acute lymphoblastic leukemia (B-ALL), and axicabtagene ciloleucel (Yescarta), marketed by Kite Pharma originally for diffuse large B-cell lymphoma (DLBCL). [15]

  8. Gilead's (GILD) CAR T Cell Therapy Yescarta Gets FDA ... - AOL

    www.aol.com/news/gileads-gild-car-t-cell...

    Gilead's (GILD) CAR T-cell therapy gets a boost with the FDA approval of Yescarta for the treatment of adult patients with relapsed or refractory follicular lymphoma.

  9. Brexucabtagene autoleucel - Wikipedia

    en.wikipedia.org/wiki/Brexucabtagene_autoleucel

    Brexucabtagene autoleucel is a chimeric antigen receptor T cell therapy and is the first cell-based gene therapy approved by the U.S. Food and Drug Administration (FDA) for the treatment of mantle cell lymphoma.