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GDF15 is being evaluated as a therapeutic target for treatment of cancer cachexia. In September 2024, Pfizer disclosed that the anti-GDF15 monoclonal antibody ponsegromab led to significant increases in body weight in patients with non-small cell lung cancer, pancreatic cancer, and colorectal cancer.
2660 17700 Ensembl ENSG00000138379 ENSMUSG00000026100 UniProt O14793 O08689 RefSeq (mRNA) NM_005259 NM_010834 RefSeq (protein) NP_005250 NP_034964 Location (UCSC) Chr 2: 190.06 – 190.06 Mb Chr 1: 53.1 – 53.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. Myostatin (also known as growth ...
The main discussion of these abbreviations in the context of drug prescriptions and other medical prescriptions is at List of abbreviations used in medical prescriptions. Some of these abbreviations are best not used, as marked and explained here.
Several members of this subfamily have been described, and named GDF1 through GDF15. GDF1 is expressed chiefly in the nervous system and functions in left-right patterning and mesoderm induction during embryonic development.
This is a list of abbreviations used in medical prescriptions, including hospital orders (the patient-directed part of which is referred to as sig codes).This list does not include abbreviations for pharmaceuticals or drug name suffixes such as CD, CR, ER, XT (See Time release technology § List of abbreviations for those).
Follistatin is studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee and McPherron demonstrated that inhibition of GDF-8, either by genetic elimination ( knockout mice ) or by increasing the amount of follistatin ...
[18 F]Fluorodeoxyglucose (), or fluorodeoxyglucose F 18 (USAN and USP), also commonly called fluorodeoxyglucose and abbreviated [18 F]FDG, 2-[18 F]FDG or FDG, is a radiopharmaceutical, specifically a radiotracer, used in the medical imaging modality positron emission tomography (PET).
GDF2 contains an N-terminal TGF-beta-like pro-peptide (prodomain) (residues 56–257) and a C-terminal transforming growth factor beta superfamily domain (325–428). [6] GDF2 (BMP9) is secreted as a pro-complex consisting of the BMP9 growth factor dimer non-covalently bound to two BMP9 prodomain molecules in an open-armed conformation.